Challenges, innovations and future directions in dengue vaccine development

Dengue fever, caused by a flavivirus named DENV, is a major global health challenge, risking almost half of the world’s population. Since the early 20th century, the scientific community has faced multiple challenges in developing effective dengue vaccines. This spanned a variety of techniques—from the use of ox bile to weaken DENV to the chemical processing of DENV-infected mosquitoes…