MHRA Drops Post-Op Pain Use for Prolonged-Release Opioids

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The Medicines and Healthcare products Regulatory Agency ( MHRA) has removed postoperative pain relief from the licensed indications of prolonged-release morphine sulphate and prolonged-release oxycodone. The decision follows concerns over persistent postoperative opioid use (PPOU) and opioid-induced ventilatory impairment (OIVI). The announcement comes after a safety review by the MHRA…

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